Idiopathic Encephalopathy Treatment with Stem Cell Therapy
The condition which leads to brain damage, disease or malfunction is generally termed as Encephalopathy. Idiopathic Encephalopathy is a critical condition that may lead to an altered mental state. There could be various factors that may lead to this condition such as drugs, toxins, metabolic problems, infections, trauma, etc.
The condition can present a wide range of symptoms, which could be mild or severe. These symptoms may lead to subtle change in personality or memory loss to severe conditions such as coma, seizures, dementia or death.
What are the Causes of Idiopathic Encephalopathy?
- Infectious (Parasites, bacteria, viruses)
- Alcohol toxicity
- Alterations in pressure within the brain (often from bleeding, tumors, or abscesses)
- Lack of oxygen to the brain
- Liver cancer or liver failure
- Kidney failure
- Brain tumors
- Metabolic diseases
- Exposure to many types of toxic chemicals like ammonia, lead or mercury
- Poor nutrition
Treatment of Idiopathic Encephalopathy
Anyone who has a head or brain injury needs immediate medical attention. The key factor is the extent and location of the damage. Brain injury does not necessarily result in long-term disability or impairment, but the correct diagnosis and treatment is needed to contain or minimize the damage.
The extent and effect of brain damage are determined by a neurological exam, neuroimaging testing such as MRI or CT scans, and neuropsychological assessments. Doctors will stabilize the patient to prevent further injury, ensure blood and oxygen are flowing properly to the brain, and ensure that blood pressure is controlled.
Almost all patients will benefit from rehabilitation to assist in long-term recovery. That may include:
- Physical therapy
- Occupational therapy
- Speech and language therapy
- Psychological support
- Stem Cell therapy for brain injury
Stem Cell Treatment of Idiopathic Encephalopathy
Stem cell treatment for Idiopathic Encephalopathy may focus on secondary brain injury, which is the result of biochemical and physiological events, ultimately leading to neuronal cell death. Recent research has indicated that the potential therapeutic benefit of stem cell therapy could be the result of the following mechanisms:
- Secrete growth factors to promote functional outcome after brain injury via neurogenesis and synaptogenesis;
- Produce and induce many cytokines and trophic factors to enhance angiogenesis and vascular stabilization in the lesion boundary zone;
- Decrease glial scar formation and promote glial-axonal remodeling;
- Differentiate into cells of neural origin including neurons, astrocytes, and glial cells.
- Stem cells, therefore, act in a pleiotropic way to stimulate brain remodeling after brain injury by influencing several neural restorative functions such as synaptogenesis, angiogenesis, and neurogenesis.
Benefits of Brain Injury Treatment
Unlike most other cells in the body, brain cells do not regenerate when they are destroyed. However, this does not mean that no recovery can occur. The brain is somewhat flexible and is able to reorganize itself, to an extent, in order to regain lost function. This is known as brain ‘plasticity’.
During recovery, other areas of the brain take over the activities of the damaged areas and new nerve pathways can be established using undamaged brain cells. Engaging in activity helps these alternative pathways to develop.
Rehabilitation aims to help the brain learn alternative ways of working in order to minimize the long-term impact of brain injury. Rehabilitation also helps the survivor and the family to cope successfully with any remaining disabilities.
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